Aristo D3 IM Injection

Company:Aristopharma Limited


Osteoporosis, Hypoparathyroidism, Rickets, Osteomalacia, Vitamin D Deficiency, Pseudohypoparathyroidism, Familial hypophosphatemia


May be taken with or without food.

Adult Dose

Oral /IM: Nutritional deficiency Cholecalciferol (Vitamin D3) is recommended 5-10 mcg or 1-2ml (200-400 IU)/day Osteoporosis Prophylaxis and treatment >50 years: 800-1000 IU (20-25 mcg) PO once daily with calcium supplements. It may also be given via IM. Hypoparathyroidism 50,000-200,000 IU (0.625-5 mg) PO once daily with calcium supplements. It may also be provided via IM.

Child Dose

Nutritional Supplementation RDA 0-12 months: 400 IU (10 mcg) PO once daily 1-18 years: 600 IU (15 mcg) PO once daily Vitamin D-Resistant Rickets 12,000-500,000 IU (0.3-12.5 mg) PO once daily Familial Hypophosphatemia 40,000-80,000 IU (1-2 mg) PO once daily with phosphate supplements; may be reduced after stage of growth is complete


Colecalciferol is contraindicated in all diseases associated with hypercalcemia. It is also contraindicated in patients with known hypersensitivity to Colecalciferol (or medicines of the same class) and any of the constituent excipients. Colecalciferol is contraindicated if there is evidence of vitamin D toxicity.

Mode of Action

Vitamin D3 is a fat-soluble sterol. It is necessary for the regulation and regulation of calcium and phosphate homeostasis and bone mineralization. Vitamin D is also essential for healthy bones as it aids in Calcium absorption from the GI tract. In addition to this, it stimulates bone formation.


People with the following conditions should exercise caution when considering taking vitamin D supplements: High blood Calcium or Phosphorus level Heart problems Kidney disease Vitamin D must be taken with adequate amounts of calcium and Magnesium supplementation. When the Calcium level is low (due to insufficient vitamin D and calcium intake), the body activates the parathyroid gland, which produces PTH (parathyroid hormone). This hormone kick starts vitamin D hormone production and assists in the removal of Calcium from the bones to be used in more important functions such as neutralizing body acidity. Lactation: The drug is distributed into breast milk; use with caution

Side Effect

Generally, all nutritional supplements are considered to be safe and well-tolerable. However, few side effects can generally occur including hypercalcemia syndrome or Calcium intoxication (depending on the severity and duration of hypercalcemia), occasional acute symptoms include anorexia, headache, dry mouth, nausea, vomiting, abdominal pain or stomach ache, and constipation with administration of Cholecalciferol.


Increased risk of hypercalcemia if given with thiazide diuretics, calcium, or phosphate. Antiepileptics (e.g. carbamazepine, phenobarbitone, phenytoin & primidone) may increase vitamin D requirements. Rifampicin & isoniazid may reduce the efficacy of vitamin D. Corticosteroids may counteract the effect of vitamin D. Digoxin or any cardiac glycoside. Reduced absorption when taken with cholestyramine, colestipol, mineral oil, or orlistat. Ketoconazole.

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