|Company:||Incepta Pharmaceuticals Ltd.|
|Generic:||Calcium Carbonate + Calcium Gluconate + Vitamin-C|
Adults: 1 effervescent tablet daily.
Calcium Carbonate: Co-administration with thiazide diuretics or vit D may lead to milk-alkali syndrome and hypercalcaemia. Decreased absorption with corticosteroids. Decreases absorption of tetracyclines, atenolol, iron, quinolones, alendronate, Na fluoride, Zn, and calcium-channel blockers. Enhances cardiac effects of digitalis glycosides and may precipitate digitalis intoxication. Calcium Gluconate: Co-admin of high calcium doses with thiazide diuretics may result in milk-alkali syndrome and hypercalcemia. May potentiate digoxin toxicity. Decreases effects of calcium-channel blockers. Enhanced absorption with calcitriol (a vitamin D metabolite). Vit C: Deferroxamine, hormonal contraceptives, fluphenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram, mexiletine, vitamin B12.
Patients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully. Periodic checks of plasma Calcium levels and urinary Calcium excretion should be made in patients with mild to moderate renal failure or mild hypercalciuria. In patients with a history of renal stones urinary Calcium excretion should be measured to exclude hypercalciuria. With long-term treatment, it is advisable to monitor serum and urinary Calcium levels and kidney function and reduce or stop treatment temporarily if urinary Calcium exceeds 7.5 mmol/24 hours. Lactation: Calcium enters human milk; use with caution
Calcium prevents or treats negative Ca balance. It also helps facilitate nerve and muscle performance as well as normal cardiac function. Bone mineral component; cofactor in enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways. Vitamin C: Necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in the conversion of folic acid to folinic acid.
Children above 7 years: 1 effervescent tablet daily. Children 3 to 7 years: 1/2 effervescent tablet daily, Infants: Dissolve one tablet in half a glass (100 ml) of water.
Nutritional Supplements in Osteoporosis, Calcium, and vitamin C deficiency, Premenstrual syndrome, Postmenopausal problems, Increased demand for Calcium and Vitamin C, pregnancy, Lactation, Periods of rapid growth (childhood, Adolescence), In old age, During infectious disease and convalescence.
Pregnancy Category Note
Anorexia, Constipation, Flatulence, Nausea, Vomiting, Hypercalcemia, Hypophosphatemia, Xerostomia, Acid rebound, Milk-alkali syndrome, Hypotension, Headache, Diarrhea.
Absolute contraindications are hypercalcemia resulting from myeloma, bone metastases or another malignant bone disease, sarcoidosis; primary hyperparathyroidism, and Vitamin-D overdosage. It is also contraindicated in severe renal failure and hypersensitivity to any of the tablet ingredients.