Dexilend 30

Specifications
Company:Ziska Pharmaceuticals Ltd.
Generic:Dexlansoprazole
Price:100tk bd

Introduction

Dexilend 30 is a medicine that reduces the amount of acid produced in your stomach. It is used for treating acid-related diseases of the stomach and intestine such as heartburn, acid reflux, peptic ulcer disease, and some other stomach conditions associated with excessive acid production. Dexilend 30 is also used to prevent stomach ulcers and acidity that may be seen with the prolonged use of painkillers. It belongs to a class of medicines known as proton pump inhibitors (PPIs). This medicine should be taken one hour before a meal, preferably in the morning. The dose will depend on your underlying condition and how you respond to the medicine. You should keep on taking it as prescribed even if your symptoms disappear quickly. You can increase the efficiency of the treatment by eating smaller meals more often and avoiding caffeinated drinks (like tea and coffee), and spicy or fatty foods. The most common side effects observed with this medicine include nausea, vomiting, flatulence, and diarrhea. These symptoms are generally mild but if they bother you or do not go away, consult your doctor. Long-term use of this medicine may lead to an increased risk of side effects. For instance, using this medicine for more than 1 year may increase your risk for bone fractures, especially with higher doses. Talk to your doctor about ways to prevent bone loss (osteoporosis), like taking calcium and vitamin D supplements. Before taking this medicine, you need to tell your doctor if you have severe liver problems, are taking medicines for HIV, have ever had an allergic reaction to similar medicines in the past or suffer from bone loss (osteoporosis). Pregnant or breastfeeding women should also consult their doctor before taking it.

Uses of Dexilend 30

  • Gastroesophageal reflux disease (Acid reflux)
  • Peptic ulcer disease

Side effects of Dexilend 30

Common

  • Nausea
  • Abdominal pain
  • Flatulence
  • Diarrhea
  • Vomiting

How to use Dexilend 30

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Dexilend 30 is to be taken empty stomach.

How Dexilend 30 works

Dexilend 30 is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

What if you forget to take Dexilend 30?

If you miss a dose of Dexilend 30, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

  • Dexilend 30 should be taken 1 hour before a meal, preferably in the morning.
  • It is a well-tolerated medicine and provides relief for a long time.
  • Avoid eating late at night or before bedtime.
  • Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
  • Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
  • Long-term use of Dexilend 30 can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or supplements as prescribed by your doctor.
  • Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.

Brief Description

Indication

Oesophagitis, Gastro-oesophageal reflux disease (GERD)

Administration

Capsule: May take with or without food DR: Take at least 30 minutes before a meal

Adult Dose

Erosive Esophagitis Capsule: Indicated for healing of all grades of erosive esophagitis (EE) and maintaining healing of EE DR: Indicated for maintaining healing of EE Healing (capsule): 60 mg PO play for up to 8 weeks Maintenance (capsule or DR): 30 mg PO play for up to 6 months Gastroesophageal Reflux Disease Indicated for treating heartburn associated with symptomatic non-erosive GERD Capsule or DR: 30 mg PO qDay for 4 weeks Hepatic impairment Milde (Child-Pugh A): Dose adjustment not necessary Moderate (Child-Pugh B): Not to exceed 30 mg/day Severe (Child-Pugh C): Not recommended

Child Dose

<12 years Safety and efficacy not established >12 years Erosive Esophagitis Capsule: Indicated for healing of all grades of erosive esophagitis (EE) and maintaining healing of EE DR: Indicated for maintaining healing of EE Healing (capsule): 60 mg PO play for up to 8 weeks Maintenance (capsule or DR): 30 mg PO play for up to 6 months Gastroesophageal Reflux Disease Indicated for treating heartburn associated with symptomatic non-erosive GERD Capsule or DR: 30 mg PO day for 4 weeks

Contraindication

Hypersensitivity.

Mode of Action

R-enantiomer of lansoprazole; PPI; binds to H+/K+-exchanging ATPase (proton pump) in gastric parietal cells, resulting in blockage of acid secretion. Dual release formulation.

Precaution

Hepatic impairment. Gastric malignancy should be ruled out. Pregnancy and lactation. Lactation Risk Summary There is no information regarding the presence of dexlansoprazole in human milk, its effects on breastfed infants, or milk production; however, lansoprazole and its metabolites are present in rat milk; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and potential adverse effects on breastfed child from therapy or the underlying maternal condition

Side Effect

1-10% Diarrhea (5%), Abdominal pain (4%), Nausea (3%), URI (2-3%), Vomiting (1-2%), Flatulence (1%) <1% (Selected) Arrhythmia, Bradycardia, Barrett’s esophagus, DVT, Dyspnea, Hepatomegaly, Hypertension, Paresthesia, Rectal hemorrhage, Vulvovaginal infection

Pregnancy Category Note

Pregnancy There are no studies with dexlansoprazole use in pregnant women to inform a drug-associated risk; dexlansoprazole is R-enantiomer of lansoprazole, and published observational studies of lansoprazole use during pregnancy did not demonstrate an association of adverse pregnancy-related outcomes with lansoprazole In animal reproduction studies, oral administration of lansoprazole to rats during organogenesis through lactation at 1.8 times the maximum recommended human dexlansoprazole dose; produced reductions in the offspring in femur weight, femur length, crown-rump length and growth plate thickness (males only) on postnatal day 21; these effects were associated with reduction in body weight gain; advise pregnant women of potential risk to fetus Lactation There is no information regarding presence of dexlansoprazole in human milk, effects on breastfed infant, or on milk production; however, lansoprazole and its metabolites are present in rat milk; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and potential adverse effects on breastfed child from therapy or from the underlying maternal condition

Interaction

Increased risk of hypomagnesemia w/ diuretics and digoxin. May decrease the plasma concentration of erlotinib, dasatinib, and lapatinib. This may decrease the bioavailability of itraconazole and ketoconazole. May increase the plasma concentration of cilostazol and methotrexate. Reduced bioavailability w/ antacids and sucralfate. Potentially Fatal: May decrease serum levels and pharmacological effects of rilpivirine and atazanavir.

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