Etorix 120

Introduction

Etorix 120 is a pain-relieving medicine. It is used for relieving moderate pain and swelling of joints associated with different forms of gout and arthritis. It is also used for short-term treatment of moderate pain after dental surgery in people 16 years of age and older.

Etorix 120 can be taken with or without food. The dose depends on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for longer than recommended. The most common side effects of this medicine include stomach pain, edema, dizziness, headache, irregular heartbeat, and increased blood pressure.

These are not usually serious but if you are worried, ask your doctor about ways of reducing or preventing them. Before taking it, you should let your doctor know if you have a history of ulcers or bleeding in your stomach, high blood pressure, or have any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Pregnant or breastfeeding women should consult their doctor before starting treatment. You should also avoid drinking alcohol while you are taking this medicine. Heavy drinking can cause excessive drowsiness.

Uses of Etorix 120

• Pain relief

Side effects of Etorix 120

Common

• Stomach pain
• Diarrhea

How to use Etorix 120

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Etorix 120 may be taken with or without food, but it is better to take it at a fixed time.

How Etorix 120 Works

Etorix 120 is a non-steroidal anti-inflammatory drug (NSAID) called COX-2 inhibitor. It works by blocking the release of certain chemical messengers that are responsible for pain and inflammation (redness and swelling).

Quick Tips

• Etorix 120 helps relieve pain and inflammation.
• It may cause fewer stomach problems as compared to other NSAIDs like Ibuprofen or Naproxen.
• It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
• Do not consume alcohol while on treatment with this medicine as it may cause excessive drowsiness.
• Regularly monitor your blood pressure while taking this medicine, particularly in the first two weeks after starting treatment.
• Inform your doctor if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease.
• During long-term treatment, your doctor may want to take regular blood tests to monitor your liver function.
• Do not take Etorix 120 if you are pregnant, planning to conceive, or breastfeeding.

Brief Description

Indication

Rheumatoid arthritis, Osteoarthritis, Gout

Administration

May be taken with or without food.

Adult Dose

Oral Osteoarthritis Adult: 30 mg once daily, increased to 60 mg once daily if needed. Ankylosing spondylitis; Rheumatoid arthritis Adult: 90 mg once daily. Acute gout Adult: 120 mg once daily. Max duration: 8 days. Hepatic impairment: Mild (Child-Pugh score of 5-6): 60 mg once daily. Moderate (Child-Pugh 7-9): Max 60 mg every other day or 30 mg once daily. Severe (Child-Pugh >10): Avoid.

Child Dose

Child: <16 yr Contraindicated.

Contraindication

Inflammatory bowel disease, severe congestive heart failure, active peptic ulceration, cerebrovascular disease, CrCL <30 ml/min; lactation. Children and adolescents < 16 yr.

Mode of Action

Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to the inhibition of prostaglandin synthesis via the inhibition of COX-2.

Precaution

Allergic disorders, coagulation defects; history of cardiac failure, left ventricular dysfunction, hypertension, or in patients with edema due to other reasons; elderly, renal, cardiac, or hepatic impairment. Withdraw treatment if GI lesions develop; caution when admin to dehydrated patients. Regular BP monitoring is advisable. May mask fever and other signs of infection. Pregnancy.

Side Effect

GI disorders; ischemic cardiac events; hypersensitivity reactions, headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, tinnitus, photosensitivity; blood disorders, fluid retention, hypertension; dry mouth, taste disturbance, mouth ulcers; appetite and wt changes; chest pain, fatigue, paraesthesia, influenza-like syndrome, myalgia. Renal toxicity.

Interaction

May increase INR w/ oral anticoagulants. May decrease the effects of ACE inhibitors, angiotensin II antagonists,s and diuretics. May increase lithium plasma concentrations. May reduce plasma levels w/ rifampicin. Increased serum concentrations of ethinylestradiol.