|Company:||Jayson Pharmaceuticals Ltd.|
Anemia, Nutritional supplement, Folic acid deficiency, Megaloblastic anemia, Neural tube defect
May be taken with or without food.
Oral Folate-deficient megaloblastic anemia Adult: 5 mg daily for 4 mth, up to 15 mg daily in malabsorption states. Continued dosing at 5 mg every 1-7 days may be needed in chronic hemolytic states, depending on the diet and rate of hemolysis. Prophylaxis of megaloblastic anemia in pregnancy Adult: 0.2-0.5 mg daily. Prophylaxis of neural tube defect in pregnancy Adult: 4 or 5 mg daily starting before pregnancy and continued through the 1st trimester. As a supplement for women of child-bearing potential Adult: 0.4 mg daily.
Folic Acid Deficiency Infants: 15 mcg/kg/day or 50 mcg/day 1-10 years: 1 mg/day initially, then 0.1-0.4 mg/day
This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. Folic Acid is contraindicated in untreated cobalamine deficiency.
Mode of Action
Folic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase; prevents neural tube defects in women of childbearing potential and higher doses required during pregnancy.
Treatment resistance may occur in patients with depressed hematopoiesis, alcoholism, and deficiencies in other vitamins. Neonates. Lactation: Drug enters breast milk; safe for nursing
Bronchospasm, Erythema, Malaise, Pruritus, Rash, Slight flushing
Pregnancy Category Note
Pregnancy category: A Lactation: Drug enters breast milk; safe for nursing
Antiepileptics, oral contraceptives, anti-TB drugs, alcohol, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides may result to decrease in serum folate contrations. Decreases serum phenytoin concentrations.