|Company:||Beximco Pharmaceuticals Ltd.|
|Generic:||Ferrous Ascorbate + Folic Acid + Zinc|
Iron, Folic Acid, and Zinc deficiency, Dietary supplements, Pregnancy, and lactation
For maximum absorption take on an empty stomach, but may take it with or after meals to minimize GI irritation
Adults: 1-2 capsules daily.
Child: Over 1 year: 1 capsule daily.
Contraindicated in patients with a known hypersensitivity to any of the ingredients. Folic Acid is contraindicated in untreated cobalamine deficiency.
Mode of Action
Ferrous ascorbate is a synthetic molecule of ascorbic acid and iron. Ferrous ascorbate is a stable complex of iron and ascorbic acid. Ascorbic acid plays an important role in the movement of plasma iron to storage depots in tissues. There is also evidence that ascorbic acid improves iron utilization, by its reducing action and it may have a direct effect on erythropoiesis. This molecule doesn’t dissociate on entering GI Tract due to the stable chelate of iron with ascorbate. There is no action of food inhibitors on it as the complex does not dissociate. Ascorbate is a reducing agent and prevents oxidation. Thus maintains iron in highly soluble ferrous form. Iron: Essential component in the formation of hemoglobin; adequate amounts of iron are necessary for effective erythropoiesis; also serves as a cofactor of several essential enzymes, including cytochromes that are involved in electron transport. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin. Folic acid: Required for nucleoprotein synthesis and the maintenance of normal erythropoiesis; folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase; prevents neural tube defects in women of childbearing potential and higher doses required during pregnancy. Zinc: Cofactor in over 100 enzymes; plays a role in DNA synthesis; supports a healthy immune system; helps maintain a sense of smell and taste; may assist in proper function of insulin.
Care should be taken in patients who may develop iron overloads, such as those with hemochromatosis, hemolytic anemia, or red cell aplasia. Iron chelates with tetracycline and absorption may be impaired.
Generally well tolerated. However, a few allergic reactions may be seen. Sometimes gastrointestinal disturbances like abdominal pain, dyspepsia, nausea, vomiting, and constipation may occur.
Concurrent admin with antacids/H2 antagonists may reduce the absorption of iron. Chloramphenicol may delay response to iron. Iron may reduce the absorption of levodopa, methyldopa, and penicillamine when given together. Absorption may be reduced when used with quinolones or tetracyclines.