|Diacerein + Glucosamine Sulphate
|Beximco Pharmaceuticals Ltd.
Rheumatoid arthritis, Osteoarthritis, Chronic low back pain
Should be taken with food. Take w/ or immediately after meals.
Oral Osteoarthritis Adults: 1 tablet twice daily
Oral Osteoarthritis Children over 12 years and older: 1 tablet twice daily
Renal impairment: CrCl (ml/min) Dosage Recommendation <30 25 mg daily.
Absorption of Diacerein is reduced if taken with aluminum and/or magnesium hydroxide antacid. Diacerein also increases the risk of diarrhea if taken with laxatives, or antibiotics. Avoid co-administration with fibers and phytic acids. Diacerein has shown hypersensitivity to anthraquinone derivatives.
Mode of Action
Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1. Glucosamine stimulates the production of proteoglycans and increases sulfate uptake by articular cartilage.
Caution should be practiced when administering Diacerein + Glucosamine Sulphate in those patients who are allergic to Glucosamine and/or Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. Before taking Diacerein + Glucosamine Sulphate complete blood count, liver function and urinalysis should be monitored regularly.
Diarrhea, constipation, epigastric pain, heartburn, nausea, vomiting, headache, skin rashes, drowsiness, intense yellow coloring of urine.
Diacerein: Decreased absorption with aluminum and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, and antibiotics. Avoid co-admin with fibres and phytates. Glucosamine: May reduce effect of antidiabetic agents, doxorubicin, etoposide, tenoposide. May enhance the anticoagulant activity of warfarin.