| Specifications | |
|---|---|
| Company: | Popular Pharmaceuticals Ltd. |
| Generic: | Calcium 600 mg + Vitamin D 400 IU |
| Price: | 160tk bd |
Indications
This medication is prescribed for individuals with calcium and vitamin D deficiencies, as well as those requiring a calcium and vitamin D supplement. It is also used in the treatment of osteoporosis.
Administration
It is recommended to take this medication with food.
Adult Dosage
For adults, the oral dosage is 1-2 tablets per day, preferably one tablet in the morning and one tablet in the evening.
Contraindications
This medication should not be used in individuals with hypercalcemia and hyperparathyroidism, hypercalciuria and nephrolithiasis, hypersensitivity to any component of this preparation, or severe renal insufficiency.
Mode of Action
The combination of calcium and vitamin D3 prevents or treats negative calcium balance. It plays a crucial role in facilitating nerve and muscle function, as well as maintaining normal cardiac performance. Calcium is an essential component of bone minerals and acts as a co-factor in enzymatic reactions, contributing to neurotransmission, muscle contraction, and various signal transduction pathways. Vitamin D3, a fat-soluble sterol, regulates calcium and phosphate homeostasis, supports bone mineralization, and enhances calcium absorption from the gastrointestinal tract. Moreover, it stimulates bone formation. Clinical studies have demonstrated the synergistic effects of calcium and vitamin D on bone growth, osteoporosis prevention, and fracture reduction.
Precautions
Discontinuation of the medication is usually sufficient to return serum calcium concentrations to normal in cases of hypercalcemia. Calcium salts should be used cautiously in patients with sarcoidosis, renal or cardiac disease, and those receiving cardiac glycosides. Patients with a history of stone formation should be advised to increase their fluid intake. During lactation, calcium and vitamin D are distributed in human breast milk. Supplementation with calcium and vitamin D according to the recommended daily allowance is advisable during pregnancy and lactation.
Side Effects
Common side effects of calcium may include anorexia, constipation, flatulence, nausea, vomiting, hypercalcemia, hypophosphatemia, xerostomia, acid rebound, and milk-alkali syndrome. Vitamin D can cause hypercalcemia, muscle and bone pain, metallic taste, headache, nausea, vomiting, dry mouth, constipation, and arrhythmias.
Pregnancy Category Note
This medication is considered safe to take during pregnancy at the recommended doses. However, it is important to avoid calcium or vitamin D overdoses during pregnancy, as prolonged hypercalcemia may lead to physical and mental development retardation, supra valvular aortic stenosis, and retinopathy in the child. High doses of vitamin D have shown toxic effects on reproduction in animal studies. There is no indication that therapeutic doses of vitamin D3 are teratogenic in humans.
Interactions
When used together, this medication may affect the absorption of tetracycline. Concurrent use with systemic corticosteroids can reduce calcium absorption. Thiazide diuretics may decrease urinary excretion of calcium. The simultaneous use of ion-exchange resins may reduce the gastrointestinal absorption of vitamin D. Hypercalcemia can increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D, necessitating monitoring of ECG and serum calcium levels. Bisphosphonate or sodium fluoride should be administered at least 3 hours before calcium-containing preparations.