|Beximco Pharmaceuticals Ltd.
How to use Neofloxin 500
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Neofloxin 500 may be taken with or without food, but it is better to take it at a fixed time. Avoid Neofloxin 500 with caffeine and chocolate as well as food containing caffeine and chocolate such as tea leaves, and cocoa beans.
How Neofloxin 500 Works
Neofloxin 500 is an antibiotic. It works by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them.
What if you forget to take Neofloxin 500?
If you miss a dose of Neofloxin 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose
- Your doctor has prescribed Neofloxin 500 to cure your infection and improve symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- Discontinue Neofloxin 500 and inform your doctor immediately if you get a rash, itchy skin, swelling of your face and mouth, or difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn’t stop or if you find blood in your stools.
- Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Renal impairment CrCl >50 mL/min: Dose adjustment not necessary CrCl 30-50 mL/min: 250-500 mg PO q12hr CrCl <30 mL/min: Extended-release, 500 mg PO q24hr CrCl 5-29 mL/min: 250-500 mg PO q18hr or 200-400 mg IV q18-24hr Some clinicians suggest decreasing dose but not frequency of administration Hemodialysis: 0.25-0.5 g PO q12hr or 0.2-0.4 g IV q24hr Peritoneal dialysis: 0.25-0.5 g PO q8hr or 0.2-0.4 g IV q24hr
Hypersensitivity. Not to be used concurrently with tizanidine. Avoid exposure to strong sunlight or sun lamps during treatment.
Mode of Action
Ciprofloxacin promotes the breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in the reproduction of bacterial DNA.
Pregnancy Category Note
Pregnancy category: C Lactation: Drug enters breast milk; use not recommended (American Academy of Pediatrics Committee states that drug is compatible with nursing)