|Globe Pharmaceuticals Ltd.
Perion 10 is a prescription medicine used in the treatment of indigestion, nausea, and vomiting. It blocks the substance on the brain that triggers nausea or vomiting and it also increases the movement of food in the stomach, thereby improving digestion. Perion 10 is taken before meals in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should take this medicine until your doctor tells you to stop. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. The most common side effects are headache, dry mouth, and stomach pain. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness. This medicine may also cause diarrhea, so it is better to take plenty of fluids while taking this medicine as it may help to prevent dehydration. Before taking this medicine you should let your doctor know if you have liver or kidney problems. You shouldn’t take it at the same time as an antacid. Pregnant women should also consult their doctor. You should avoid this medicine if suffering from bleeding ulcers of the stomach.
Uses of Perion 10
Side effects of Perion 10
- Dryness in mouth
- Stomach pain
How to use Perion 10
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Perion 10 is to be taken empty stomach.
How Perion 10 works
Perion 10 is a prokinetic. It works on the region in the brain that controls vomiting. It also acts on the upper digestive tract to increase the movement of the stomach and intestines, allowing food to move more easily through the stomach.
What if you forget to take Perion 10?
If you miss a dose of Perion 10, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
- Perion 10 helps relieve nausea, vomiting and indigestion.
- It should be taken before meals as per the dose and duration prescribed by your doctor.
- It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
- Avoid consuming alcohol when taking Perion 10 as it may cause excessive drowsiness.
- Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake, and sugarless candy may help.
- Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
- Do not take it for longer than 7 days without consulting your doctor.
Gastritis, Lactation, Migraine, Nausea and vomiting, Gastroparesis, Nonulcer dyspepsia
It should be taken on an empty stomach. Take 15-30 min before meals.
Oral Adults: Nausea and vomiting 10-20 mg 4-8 hrly. Max: 80 mg/day. Nonulcer dyspepsia 10 mg 3-4 times daily. Max: 20 mg 3-4 times daily. The last dose is to be taken at bedtime. Migraine 20 mg 4 hrly. Max: 4 doses/24 hr. Rectal: Nausea and vomiting 60 mg twice daily. Elderly: No dosage adjustment is needed. Hepatic impairment: No dosage adjustment is needed.
Oral Children : 0.2 – 0.4 mg/kg every 4 – 8 hours daily. Rectal Child: <12 yr >15 kg: 30 mg bid; >12 yr >35 kg: 60 mg bid.
Renal impairment: Mild to moderate: No dosage adjustment needed. Severe: Reduce dose to 1-2 times daily w/ prolonged treatment.
Hypersensitivity. GI hemorrhage, obstruction, and perforation, patients with prolactin-releasing pituitary hormone, chronic admin, or routine prophylaxis of postoperative nausea and vomiting.
Mode of Action
Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, enhances gastroduodenal coordination, and lowers oesophageal sphincter pressure, gastric motility, and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time.
Phaeochromocytoma; children<2 yr, elderly; renal or hepatic impairment. Risk of cardiac arrhythmias and hypokalaemia if administered IV. Pregnancy and lactation.
Drowsiness, extrapyramidal reactions, galactorrhoea, gynaecomastia; constipation or diarrhea, lassitude, decreased libido, skin rash, itch. Potentially Fatal: Convulsions, arrhythmias, and cardiac arrest, dysrhythmias in patients with CV disease or hypokalaemia, and patients on cancer chemotherapy. Seizures; hypertensive crisis in patients with phaeochromocytoma.
May antagonize the hyperprolactinemic effect of bromocriptine. May antagonize the prokinetic effect w/ opioid analgesics and antimuscarinics. Potentially Fatal: Potent CYP3A4 inhibitors (e.g. ketoconazole, erythromycin, or ritonavir) may increase serum domperidone levels and subsequently increase the risk of QT prolongation.