|Company:||General Pharmaceuticals Ltd.|
S-Citapram 5 is widely prescribed to treat depression and other mental health conditions like anxiety, panic disorder, and obsessive-compulsive disorder. It is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). S-Citapram 5 helps many people to recover from depression by improving their mood and relieving anxiety and tension. It can be taken with or without food. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. Your doctor may start you on a lower dose and increase it gradually. Do not change the dose or stop taking it without talking to your doctor, even if you feel well. Doing so may make your condition worse or you may suffer from unpleasant withdrawal symptoms (anxiety, restlessness, palpitations, dizziness, sleep disturbances, etc). To get the most benefit, take this medicine regularly at the same time each day. Your doctor may advise you to take it in the morning if you have trouble sleeping. It may take a few weeks before you start feeling better. Let your doctor know if you do not see any improvement even after 4 weeks. Some common side effects of this medicine include nausea, fatigue, increased sweating, insomnia (difficulty in sleeping), decreased sexual drive, delayed ejaculation, and women may experience difficulties achieving orgasm. Some people may experience sleepiness after taking this medicine. Let your doctor know straight away if you develop any sudden worsening of mood or any thoughts about harming yourself. Before taking S-Citapram 5, you should tell your doctor if you have epilepsy (seizure disorder or fits), diabetes, liver or kidney disease, any heart problems, or are currently taking medicines for depression known as MAO inhibitors. These may affect your treatment. Please tell your doctor about all the medicines you are taking to make sure you are safe.
Uses of S-Citapram 5
- Panic disorder
- Obsessive-compulsive disorder
Side Effects of S-Citapram 5
- Anorgasmia (decreased orgasm) in women
- Decreased libido
- Delayed ejaculation
- Increased sweating
- Insomnia (difficulty in sleeping)
How to use S-Citapram 5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. S-Citapram 5 may be taken with or without food, but it is better to take it at a fixed time.
How S-Citapram 5 works
S-Citapram 5 is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of anxiety, panic attacks, and obsessive-compulsive disorders.
What if you forget to take S-Citapram 5?
If you miss a dose of S-Citapram 5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
- Take it in the morning since it can keep you awake if taken late at night.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- It has a lower chance of causing sexual dysfunction than other similar medications.
- The addiction or dependence potential of S-Citapram 5 is very less.
- Do not stop taking the medication suddenly without talking to your doctor first.
- Some people can develop dizziness or drowsiness after taking this medicine. Do not drive or do anything that requires mental focus until you know how this medicine affects you
Major depressive disorder, Depression, Panic disorder, Obsessive-compulsive disorder, Anxiety disorder
May be taken with or without food.
Oral Anxiety; Depression; Obsessive-compulsive disorder Adult: 10 mg once daily, increased after at least a wk if needed. Max: 20 mg once daily. Panic disorder with or without agoraphobia Adult: Initially, 5 mg once daily, increased after a wk to 10 mg once daily. Max: 20 mg daily. Elderly: Half the adult dose. Hepatic impairment: Mild to moderate: Initially, 5 mg daily, increased to 10 mg daily after 2 wk if needed. Severe: More careful dose titration is needed.
Major Depressive Disorder <12 years: Safety and efficacy not established >12 years: 10 mg PO quay; may increase the dose after at least 3 weeks; not to exceed 20 mg/day
Concomitant use with or within 2 wk of MAOI withdrawal.
Mode of Action
Escitalopram selectively inhibits CNS neuronal re-uptake of serotonin (5-HT) and potentiates serotonergic activity. It has minimal effects on norepinephrine and dopamine neuronal reuptake.
History of mania or seizure disorders; work requiring mental alertness; renal and hepatic impairment; pregnancy, lactation; withdraw gradually. Lactation Excreted in breast milk; consider risk/benefit ratio
>10% Headache (24%), Nausea (18%), Ejaculation disorder (9-14%), Somnolence (4-13%), Insomnia (7-12%) 1-10% Xerostomia (4-9%), Constipation (3-6%), Fatigue (2-8%), Libido decrease (3-7%), Anorgasmia (2-6%), Flatulence (2%), Toothache (2%), Weight gain (1%), Menstrual disorder (2%), Neck/shoulder pain (3%), Rhinitis (5%), Flu-like syndrome (5%), Ejaculation disorder (9-14%) <1% Arthralgia, Abdominal pain, Abnormal bleeding, Abnormal dreams, Allergy, Blurred vision, Bronchitis, Chest pain, Constipation, Decreased appetite, Decreased concentration, Disrupts platelets/hemostasis, Dizziness, Dyspepsia, Fever, Heartburn, Hot flashes, Impotence, Irritability, Jaw stiffness, Lethargy, Lightheadedness, Menstrual disorder, Hypertension, Palpitations, Migraine, Myalgia, Paresthesia, Rash, Sweating, Tinnitus, Tremor, Urinary frequency, Urinary tract infection, Vertigo, Vomiting, Yawning
Pregnancy Category Note
Pregnancy There are no adequate and well-controlled studies in pregnant women; therefore, use during pregnancy only if the potential benefit justifies the potential risk to the fetus In some cases, the clinical picture is consistent with serotonin syndrome Effect on labor and delivery in humans is unknown Neonates exposed to escitalopram and other SSRIs/SNRIs Neonates exposed to SSRIs/SNRIs late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding Such complications can arise immediately upon delivery Reported clinical findings include respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hypertonia, hyperreflexia, tremor, jitteriness, irritability, and constant crying These features are consistent with toxic effects of SSRIs and SNRIs or, possibly, drug discontinuation syndrome Lactation Escitalopram is excreted in human breast milk Limited data from women taking 10-20 mg escitalopram showed that exclusively breast-fed infants receive a ~3.9% of the maternal weight-adjusted dose of escitalopram and 1.7% of the maternal weight-adjusted dose of desmethylcitalopram Caution should be exercised and breastfeeding infants should be observed for adverse reactions when administered to a nursing woman
Increased risk of bleeding when used with aspirin, NSAIDs, or drugs that affect coagulation. Serum levels may be reduced by CYP2C19 inducers (e.g. carbamazepine, rifampin, phenytoin) or CYP3A4 inducers (e.g. nafcillin, nevirapine). Serum levels may also be increased by CYP2C19 inhibitors (e.g. fluconazole, fluvoxamine, omeprazole) or CYP3A4 inhibitors (e.g. azole antifungals, clarithromycin). May increase serum levels of desipramine or metoprolol. Increased risk of serotonin syndrome when used with linezolid or sibutramine. Escitalopram may enhance the sedative effects of alcohol. Potentially Fatal: Concomitant administration with MAOIs may lead to serious or fatal reactions; should not be started until at least 2 wk after stopping escitalopram or vice versa. Moclobemide may increase the risk of serotonin syndrome.